ISOLEUCINE-VALINE REQUIRING MUTANTS OF SALMONELLA TYPHIMURIUM
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چکیده
منابع مشابه
Isoleucine - Valine Requiring Mutants of Salmonella Typhimurium
E have isolated a number of mutant strains of Salmonella typhimurium that display a marked inhibition of growth when valine is added to minimal medium. Attempts to elucidate the nature of the mutation(s) in these valinesensitive strains have included enzymatic and transductional analyses, as well as growth studies, on four of these strains. The results of these studies are presented and discuss...
متن کاملIsoleucine-valine Requiring Mutants of Salmonella Typhimurium.
initial reports on the mutant strains of Salmonella typhimurium that T: eui r both isoleucine and valine for growth (ilva strains) were published concomitantly by GLANVILLE and DEMEREC ( 1960) and WAGNER and BERGQUIST (1960). These studies showed that although the available ilva strains could be divided into four complementation groups ( A , B , C and D ) on the basis of abortive transduction r...
متن کاملIsoleucine-valine requiring mutants of Salmonella typhimurium. II. Strains deficient in dihydroxyacid dehydratase activity.
MONG the available isoleucine-valine requiring strains of Salmonella t yphiA murium (termed ilu) are a number of mutants deficient in CY, p-dihydroxyacid dehydratase4 activity (ARMSTRONG and WAGNER 1964). The production of this enzyme is under the control of the iluD gene (WAGNER and BERGQUIST 1960). This report is concerned with transductional analyses that have been carried out using the iZuD...
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One would expect that the mutational loss of cytidine triphosphate synthetase (Fig. 1) reaction (9) would result in a strain which requires cytosine or cytidine for growth; however, to our knowledge, no such mutants have been isolated (B. Magasanik, p. 295-334, In I. C. Gunsalus and R. Y. Stanier [ed.], The Bacteria, vol. 3. Academic Press, Inc., New York, 1962). Failure to isolate mutants with...
متن کاملGenetic and Biochemical Studies on Isoleucine and Valine Requiring Mutants of ESCHERICHIA COLI.
N microorganisms, a single mutation event can result in the growth require’ ment of two amino acids, isoleucine and valine. This is not considered unusual since the two amino acids share a common biosynthetic pathway (UMBARGER and DAVIS 1962), (Figure 1). In Salmonella typhimurium (GLANVILLE and DEMEREC 1960), the genes controlling the synthesis of the enzymes of the isoleucine-valine pathway a...
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ژورنال
عنوان ژورنال: Genetics
سال: 1964
ISSN: 1943-2631
DOI: 10.1093/genetics/50.5.957